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Why are so many MLL lysine methyltransferases required for normal mammalian development?
Crump, Nicholas T; Milne, Thomas A.
Afiliação
  • Crump NT; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Milne TA; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. thomas.milne@imm.ox.ac.uk.
Cell Mol Life Sci ; 76(15): 2885-2898, 2019 Aug.
Article em En | MEDLINE | ID: mdl-31098676
The mixed lineage leukemia (MLL) family of proteins became known initially for the leukemia link of its founding member. Over the decades, the MLL family has been recognized as an important class of histone H3 lysine 4 (H3K4) methyltransferases that control key aspects of normal cell physiology and development. Here, we provide a brief history of the discovery and study of this family of proteins. We address two main questions: why are there so many H3K4 methyltransferases in mammals; and is H3K4 methylation their key function?
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Histona-Lisina N-Metiltransferase / Proteína de Leucina Linfoide-Mieloide Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Histona-Lisina N-Metiltransferase / Proteína de Leucina Linfoide-Mieloide Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article