Synthesis and comparison of substituted 1,2,3-dithiazole and 1,2,3-thiaselenazole as inhibitors of the feline immunodeficiency virus (FIV) nucleocapsid protein as a model for HIV infection.
Bioorg Med Chem Lett
; 29(14): 1765-1768, 2019 07 15.
Article
em En
| MEDLINE
| ID: mdl-31101470
ABSTRACT
We report the first biological evaluation the 1,2,3-thiaselenazole class of compound and utilising a concise synthetic approach of sulfur extrusion, selenium insertion of the 1,2,3-dithiazoles. We created a small diverse library of compounds to contrast the two ring systems. This approach has highlighted new structure activity relationship insights and lead to the development of sub-micro molar anti-viral compounds with reduced toxicity. The 1,2,3-thiaselenazole represents a new class of potential compounds for the treatment of FIV and HIV.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Infecções por HIV
/
Vírus da Imunodeficiência Felina
/
Proteínas do Nucleocapsídeo
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article