Progranulin Promotes Bleomycin-Induced Skin Sclerosis by Enhancing Transforming Growth Factor-ß/Smad3 Signaling through Up-Regulation of Transforming Growth Factor-ß Type I Receptor.

Yang, Ting; Zhang, Xuemei; Chen, Aijun; Xiao, Yunju; Sun, Si; Yan, Jurong; Cao, Yuwei; Chen, Jin; Li, Fengzeng; Zhang, Qun; Huang, Kun

Yang, Ting; Zhang, Xuemei; Chen, Aijun; Xiao, Yunju; Sun, Si; Yan, Jurong; Cao, Yuwei; Chen, Jin; Li, Fengzeng; Zhang, Qun; Huang, Kun.

Afiliação

Yang T; Key Laboratory of Diagnostic Medicine designated by the Ministry of Education, Chongqing Medical University, Chongqing, People's Republic of China.
Zhang X; Key Laboratory of Diagnostic Medicine designated by the Ministry of Education, Chongqing Medical University, Chongqing, People's Republic of China.
Chen A; Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Xiao Y; Key Laboratory of Diagnostic Medicine designated by the Ministry of Education, Chongqing Medical University, Chongqing, People's Republic of China.
Sun S; Key Laboratory of Diagnostic Medicine designated by the Ministry of Education, Chongqing Medical University, Chongqing, People's Republic of China.
Yan J; Key Laboratory of Diagnostic Medicine designated by the Ministry of Education, Chongqing Medical University, Chongqing, People's Republic of China.
Cao Y; Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Chen J; Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Li F; Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Zhang Q; Clinical Laboratories Center, Affiliated Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Huang K; Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China. Electronic address: huangkun@hospital.cqmu.edu.cn.

Am J Pathol ; 189(8): 1582-1593, 2019 08.

Article em En | MEDLINE | ID: mdl-31108104

Assuntos

Bleomicina/efeitos adversos; Progranulinas/biossíntese; Receptor do Fator de Crescimento Transformador beta Tipo I/metabolismo; Escleroderma Sistêmico/metabolismo; Transdução de Sinais/efeitos dos fármacos; Proteína Smad3/metabolismo; Fator de Crescimento Transformador beta/metabolismo; Regulação para Cima/efeitos dos fármacos; Animais; Bleomicina/farmacologia; Feminino; Humanos; Camundongos; Camundongos Knockout; Pessoa de Meia-Idade; Progranulinas/genética; Receptor do Fator de Crescimento Transformador beta Tipo I/genética; Escleroderma Sistêmico/induzido quimicamente; Escleroderma Sistêmico/genética; Escleroderma Sistêmico/patologia; Transdução de Sinais/genética; Proteína Smad3/genética; Fator de Crescimento Transformador beta/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Escleroderma Sistêmico / Bleomicina / Transdução de Sinais / Regulação para Cima / Fator de Crescimento Transformador beta / Proteína Smad3 / Progranulinas / Receptor do Fator de Crescimento Transformador beta Tipo I Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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