A rare case of methotrexate and primaquine co-administration in a mantle cell lymphoma patient.
J Clin Pharm Ther
; 44(5): 800-804, 2019 Oct.
Article
em En
| MEDLINE
| ID: mdl-31111511
ABSTRACT
WHAT IS KNOWN AND OBJECTIVE:
High-dose methotrexate (HD-MTX) is associated with a plethora of adverse drug reactions and potential drug interactions (DIs). But there is a paucity of information regarding the safety of co-administering primaquine with HD-MTX. CASESUMMARY:
A 65-year-old male patient was diagnosed with mantle cell lymphoma (MCL) with CNS involvement and treated with three cycles of IV HD-MTX. His case was further complicated by fungal pneumonia treated with primaquine during cycle-2. Serial blood sampling and subsequent population pharmacokinetics (PK) modelling suggests a possible distribution-mediated DI between the two drugs. WHAT IS NEW ANDCONCLUSION:
This is the first case report to highlight the safe co-administration of MTX and primaquine, despite a possible PK interaction.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Primaquina
/
Metotrexato
/
Linfoma de Célula do Manto
/
Antimetabólitos Antineoplásicos
Tipo de estudo:
Prognostic_studies
Limite:
Aged
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article