Common E-Cigarette Flavoring Chemicals Impair Neutrophil Phagocytosis and Oxidative Burst.
Chem Res Toxicol
; 32(6): 982-985, 2019 06 17.
Article
em En
| MEDLINE
| ID: mdl-31117350
ABSTRACT
E-cigarette flavorings have not been thoroughly evaluated for inhalational toxicity. We have shown that the flavoring chemical cinnamaldehyde impairs human neutrophils, macrophages, and natural killer cells. Here we investigated the effects of other common e-liquid flavoring chemicals on phagocytosis and oxidative burst in neutrophils. We demonstrate that cinnamaldehyde and ethyl vanillin dose-dependently decrease oxidative burst and that benzaldehyde and benzaldehyde propylene glycol acetal dose-dependently impair phagocytosis. Isoamyl acetate did not affect either measure of neutrophil function. These data suggest that inhaling aromatic aldehydic flavoring chemicals, such as cinnamaldehyde, benzaldehyde, benzaldehyde propylene glycol acetal, or ethyl vanillin, could impair neutrophil function.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fagocitose
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Benzaldeídos
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Acroleína
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Explosão Respiratória
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Aromatizantes
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Sistemas Eletrônicos de Liberação de Nicotina
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Neutrófilos
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article