An enhanced charge-driven intranasal delivery of nicardipine attenuates brain injury after intracerebral hemorrhage.
Int J Pharm
; 566: 46-56, 2019 Jul 20.
Article
em En
| MEDLINE
| ID: mdl-31121211
ABSTRACT
Intranasal drug delivery provided an alternative and effective approach for the intervention of an intracerebral hemorrhage (ICH). However, the short retention time at the absorption site and slow drug transport in intranasal gel influence the drug bioavailability and outcome of ICH. Herein, we fabricated a novel intranasal gel with oriented drug migration utilizing a charge-driven strategy to attenuate brain injury after ICH. Nicardipine hydrochloride (NCD) was entrapped in chitosan nanoparticles (CS NPs) and dispersed in an HAMC gel. Subsequently, one side of the gel was coated with a positively charged film. The oriented migration of CS NPs in the HAMC gel was determined, and the drug bioavailability was also enhanced. Furthermore, a blood-induced ICH rat model was established to evaluate the therapeutic effect of CS NPsâ¯+â¯HAMC composites. Intranasal administration of the CS NPsâ¯+â¯HAMC (+) composite showed a stronger neuroprotective effect in terms of brain edema reduction and neural apoptosis inhibition compared to the CS NPsâ¯+â¯HAMC composite. These results suggested that the oriented and rapid drug transport from nose to brain can be achieved using the charge-driven strategy, and this intranasal drug delivery system has the potential to provide a new therapeutic strategy for the treatment of ICH.
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Base de dados:
MEDLINE
Assunto principal:
Lesões Encefálicas
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Portadores de Fármacos
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Nicardipino
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Hemorragia Cerebral
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Fármacos Neuroprotetores
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article