Copper-mediated anomeric O-arylation with organoboron reagents.
Org Biomol Chem
; 17(23): 5671-5674, 2019 06 12.
Article
em En
| MEDLINE
| ID: mdl-31123748
ABSTRACT
Copper-mediated couplings of arylboroxines with glycosyl hemiacetals furnish O-aryl glycosides via Csp2-O bond formation. The method enables the anomeric O-arylation of protected pyranose and furanose derivatives, and is tolerant of functionalized arylboroxine partners. Whereas mixtures of anomers are formed from glucopyranose, galactopyranose and arabinofuranose hemiacetals, the α-anomer is generated selectively from mannopyranose and mannofuranose-derived substrates.
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MEDLINE
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article