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Transformation of Santonin to a Naproxen Analogue with Anti-Inflammatory Activity.
Singh, Rohit; Mandrah, Kapil; Asati, Ankita; Patel, Devendra K; Goel, Bharat; Vishwakarma, Ram A; Roy, Somendu K; Jain, Shreyans K.
Afiliação
  • Singh R; Medicinal Chemistry Division and Natural Product Chemistry Division , Indian Institute of Integrative Medicine (CSIR) , Canal Road , Jammu - 180001 , India.
  • Mandrah K; Academy of Scientific & Innovative Research (AcSIR), at CSIR-IIIM, Jammu and CSIR-IITR , Lucknow - 226016 , India.
  • Asati A; Academy of Scientific & Innovative Research (AcSIR), at CSIR-IIIM, Jammu and CSIR-IITR , Lucknow - 226016 , India.
  • Patel DK; Analytical Chemistry Laboratory, Regulatory Toxicology , Indian Institute of Toxicology Research (CSIR) , Vishvigyan Bhavan 31 , Mahatma Gandhi Marg, Lucknow - 226001 , Uttar Pradesh , India.
  • Goel B; Academy of Scientific & Innovative Research (AcSIR), at CSIR-IIIM, Jammu and CSIR-IITR , Lucknow - 226016 , India.
  • Vishwakarma RA; Analytical Chemistry Laboratory, Regulatory Toxicology , Indian Institute of Toxicology Research (CSIR) , Vishvigyan Bhavan 31 , Mahatma Gandhi Marg, Lucknow - 226001 , Uttar Pradesh , India.
  • Roy SK; Academy of Scientific & Innovative Research (AcSIR), at CSIR-IIIM, Jammu and CSIR-IITR , Lucknow - 226016 , India.
  • Jain SK; Analytical Chemistry Laboratory, Regulatory Toxicology , Indian Institute of Toxicology Research (CSIR) , Vishvigyan Bhavan 31 , Mahatma Gandhi Marg, Lucknow - 226001 , Uttar Pradesh , India.
J Nat Prod ; 82(6): 1710-1713, 2019 06 28.
Article em En | MEDLINE | ID: mdl-31125226
Santonin, a natural product, was aromatized with molecular iodine as the catalyst. The new compound was characterized as ( S)-methyl-2-(7-hydroxy-5,8-dimethylnaphthalen-2-yl) propanoate (2) based on 2D NMR spectroscopic data. Structurally, compound 2 was highly similar to the anti-inflammatory drug naproxen. The new naproxen analogue had significant potency against cyclooxygenase 1 and 2 (IC50 = 31.0 and 66.1 µM, respectively).
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Santonina / Anti-Inflamatórios não Esteroides / Naproxeno / Inibidores de Ciclo-Oxigenase / Ciclo-Oxigenase 1 / Ciclo-Oxigenase 2 / Anti-Inflamatórios Idioma: En Ano de publicação: 2019 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Santonina / Anti-Inflamatórios não Esteroides / Naproxeno / Inibidores de Ciclo-Oxigenase / Ciclo-Oxigenase 1 / Ciclo-Oxigenase 2 / Anti-Inflamatórios Idioma: En Ano de publicação: 2019 Tipo de documento: Article