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An Oncolytic Adenovirus Targeting Transforming Growth Factor ß Inhibits Protumorigenic Signals and Produces Immune Activation: A Novel Approach to Enhance Anti-PD-1 and Anti-CTLA-4 Therapy.
Yang, Yuefeng; Xu, Weidong; Peng, Di; Wang, Hao; Zhang, Xiaoyan; Wang, Hua; Xiao, Fengjun; Zhu, Yitan; Ji, Yuan; Gulukota, Kamalakar; Helseth, Donald L; Mangold, Kathy A; Sullivan, Megan; Kaul, Karen; Wang, Edward; Prabhakar, Bellur S; Li, Jinnan; Wu, Xuejie; Wang, Lisheng; Seth, Prem.
Afiliação
  • Yang Y; Gene Therapy Program, Department of Medicine, NorthShore Research Institute, an Affiliate of the University of Chicago, Evanston, Illinois.
  • Xu W; Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing, China.
  • Peng D; Gene Therapy Program, Department of Medicine, NorthShore Research Institute, an Affiliate of the University of Chicago, Evanston, Illinois.
  • Wang H; Department of Urology, The Third Medical Center of Chinese People's Liberation Army, Beijing, China.
  • Zhang X; Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing, China.
  • Wang H; Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing, China.
  • Xiao F; Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing, China.
  • Zhu Y; Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing, China.
  • Ji Y; Program of Computational Genomics and Medicine, Department of Surgery; NorthShore University HealthSystem, Evanston, Illinois.
  • Gulukota K; Program of Computational Genomics and Medicine, Department of Surgery; NorthShore University HealthSystem, Evanston, Illinois.
  • Helseth DL; Center for Personalized Medicine, Department of Surgery; NorthShore University HealthSystem, Evanston, Illinois.
  • Mangold KA; Center for Personalized Medicine, Department of Surgery; NorthShore University HealthSystem, Evanston, Illinois.
  • Sullivan M; Department of Pathology and Laboratory Medicine, NorthShore University HealthSystem, Evanston, Illinois.
  • Kaul K; Department of Pathology and Laboratory Medicine, NorthShore University HealthSystem, Evanston, Illinois.
  • Wang E; Department of Pathology and Laboratory Medicine, NorthShore University HealthSystem, Evanston, Illinois.
  • Prabhakar BS; Biostatistics and Clinical Research Informatics, Department of Surgery; NorthShore University HealthSystem, Evanston, Illinois.
  • Li J; Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois.
  • Wu X; Department of Urology, The Third Medical Center of Chinese People's Liberation Army, Beijing, China.
  • Wang L; Department of Urology, The Third Medical Center of Chinese People's Liberation Army, Beijing, China.
  • Seth P; Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing, China.
Hum Gene Ther ; 30(9): 1117-1132, 2019 09.
Article em En | MEDLINE | ID: mdl-31126191
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Adenoviridae / Fator de Crescimento Transformador beta / Vírus Oncolíticos / Terapia Viral Oncolítica / Vetores Genéticos / Imunidade Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Adenoviridae / Fator de Crescimento Transformador beta / Vírus Oncolíticos / Terapia Viral Oncolítica / Vetores Genéticos / Imunidade Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article