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A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78.
Ambrose, Andrew J; Zerio, Christopher J; Sivinski, Jared; Schmidlin, Cody J; Shi, Taoda; Ross, Alison B; Widrick, Kimberly J; Johnson, Steven M; Zhang, Donna D; Chapman, Eli.
Afiliação
  • Ambrose AJ; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 1703 East Mabel Street, PO Box 210207, Tucson, AZ 85721, USA.
  • Zerio CJ; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 1703 East Mabel Street, PO Box 210207, Tucson, AZ 85721, USA.
  • Sivinski J; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 1703 East Mabel Street, PO Box 210207, Tucson, AZ 85721, USA.
  • Schmidlin CJ; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 1703 East Mabel Street, PO Box 210207, Tucson, AZ 85721, USA.
  • Shi T; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 1703 East Mabel Street, PO Box 210207, Tucson, AZ 85721, USA.
  • Ross AB; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 1703 East Mabel Street, PO Box 210207, Tucson, AZ 85721, USA.
  • Widrick KJ; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 1703 East Mabel Street, PO Box 210207, Tucson, AZ 85721, USA.
  • Johnson SM; Indiana University, School of Medicine, Department of Biochemistry and Molecular Biology, 635 Barnhill Dr., Indianapolis, IN 46202, USA.
  • Zhang DD; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 1703 East Mabel Street, PO Box 210207, Tucson, AZ 85721, USA.
  • Chapman E; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 1703 East Mabel Street, PO Box 210207, Tucson, AZ 85721, USA. Electronic address: chapman@pharmacy.arizona.edu.
Bioorg Med Chem Lett ; 29(14): 1689-1693, 2019 07 15.
Article em En | MEDLINE | ID: mdl-31129054
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Choque Térmico HSP70 / Ensaios de Triagem em Larga Escala / Hexaclorofeno Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Choque Térmico HSP70 / Ensaios de Triagem em Larga Escala / Hexaclorofeno Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article