Mechanical forces rewire metabolism in the tumor niche.
Mol Cell Oncol
; 6(3): 1592945, 2019.
Article
em En
| MEDLINE
| ID: mdl-31131310
ABSTRACT
Tumor niche extracellular matrix stiffening and tumor cell metabolic reprogramming are two fundamental mediators of tumor progression. We recently elucidated a mechanistic interconnection between mechanotransduction and tumor metabolic rewiring in cancer. We demonstrated a stiffness-dependent amino acid crosstalk between stromal and cancer cells that fuels tumor progression and metastatic spreading.
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MEDLINE
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En
Ano de publicação:
2019
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Article