The viral protein corona directs viral pathogenesis and amyloid aggregation.
Nat Commun
; 10(1): 2331, 2019 05 27.
Article
em En
| MEDLINE
| ID: mdl-31133680
ABSTRACT
Artificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses share many biophysical properties with artificial nanoparticles in extracellular environments and here we show that respiratory syncytial virus (RSV) and herpes simplex virus type 1 (HSV-1) accumulate a rich and distinctive protein corona in different biological fluids. Moreover, we show that corona pre-coating differentially affects viral infectivity and immune cell activation. In addition, we demonstrate that viruses bind amyloidogenic peptides in their corona and catalyze amyloid formation via surface-assisted heterogeneous nucleation. Importantly, we show that HSV-1 catalyzes the aggregation of the amyloid ß-peptide (Aß42), a major constituent of amyloid plaques in Alzheimer's disease, in vitro and in animal models. Our results highlight the viral protein corona as an acquired structural layer that is critical for viral-host interactions and illustrate a mechanistic convergence between viral and amyloid pathologies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
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Peptídeos beta-Amiloides
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Vírus Sincicial Respiratório Humano
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Herpesvirus Humano 1
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Interações Hospedeiro-Patógeno
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Coroa de Proteína
Tipo de estudo:
Etiology_studies
Limite:
Animals
/
Female
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Humans
/
Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article