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A coiled-coil masking domain for selective activation of therapeutic antibodies.
Trang, Vivian H; Zhang, Xinqun; Yumul, Roma C; Zeng, Weiping; Stone, Ivan J; Wo, Serena W; Dominguez, Melissa M; Cochran, Julia H; Simmons, Jessica K; Ryan, Maureen C; Lyon, Robert P; Senter, Peter D; Levengood, Matthew R.
Afiliação
  • Trang VH; Department of Protein Sciences, Seattle Genetics Inc., Bothell, WA, USA.
  • Zhang X; Department of Protein Sciences, Seattle Genetics Inc., Bothell, WA, USA.
  • Yumul RC; Department of Nonclinical Science, Seattle Genetics Inc., Bothell, WA, USA.
  • Zeng W; Department of Nonclinical Science, Seattle Genetics Inc., Bothell, WA, USA.
  • Stone IJ; Department of Nonclinical Science, Seattle Genetics Inc., Bothell, WA, USA.
  • Wo SW; Department of Protein Sciences, Seattle Genetics Inc., Bothell, WA, USA.
  • Dominguez MM; Department of Protein Sciences, Seattle Genetics Inc., Bothell, WA, USA.
  • Cochran JH; Department of Protein Sciences, Seattle Genetics Inc., Bothell, WA, USA.
  • Simmons JK; Department of Nonclinical Science, Seattle Genetics Inc., Bothell, WA, USA.
  • Ryan MC; Department of Antibody Discovery, Seattle Genetics Inc., Bothell, WA, USA.
  • Lyon RP; Department of Protein Sciences, Seattle Genetics Inc., Bothell, WA, USA.
  • Senter PD; Department of Chemistry, Seattle Genetics Inc., Bothell, WA, USA.
  • Levengood MR; Department of Protein Sciences, Seattle Genetics Inc., Bothell, WA, USA. mlevengood@seagen.com.
Nat Biotechnol ; 37(7): 761-765, 2019 07.
Article em En | MEDLINE | ID: mdl-31133742
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Anticorpos Monoclonais / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Anticorpos Monoclonais / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article