Varying levels of X chromosome coalescence in female somatic cells alters the balance of X-linked dosage compensation and is implicated in female-dominant systemic lupus erythematosus.

Laskowski, Agnieszka I; Neems, Daniel S; Laster, Kyle; Strojny-Okyere, Chelsee; Rice, Ellen L; Konieczna, Iwona M; Voss, Jessica H; Mathew, James M; Leventhal, Joseph R; Ramsey-Goldman, Rosalind; Smith, Erica D; Kosak, Steven T

Laskowski, Agnieszka I; Neems, Daniel S; Laster, Kyle; Strojny-Okyere, Chelsee; Rice, Ellen L; Konieczna, Iwona M; Voss, Jessica H; Mathew, James M; Leventhal, Joseph R; Ramsey-Goldman, Rosalind; Smith, Erica D; Kosak, Steven T.

Afiliação

Laskowski AI; Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Neems DS; Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Laster K; Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Strojny-Okyere C; Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Rice EL; Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Konieczna IM; Comprehensive Transplant Center, Department of Medicine, Surgery Division, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Voss JH; Comprehensive Transplant Center, Department of Medicine, Surgery Division, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Mathew JM; Comprehensive Transplant Center, Department of Medicine, Surgery Division, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Leventhal JR; Comprehensive Transplant Center, Department of Medicine, Surgery Division, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Ramsey-Goldman R; Deparment of Medicine, Rheumatology Division, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Smith ED; Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Kosak ST; Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. s-kosak@northwestern.edu.

Sci Rep ; 9(1): 8011, 2019 05 29.

Article em En | MEDLINE | ID: mdl-31142749

Assuntos

Mecanismo Genético de Compensação de Dose/genética; Lúpus Eritematoso Sistêmico/genética; RNA Longo não Codificante/genética; Cromossomo X/genética; Animais; Núcleo Celular/genética; Diploide; Desenvolvimento Embrionário/genética; Feminino; Regulação da Expressão Gênica no Desenvolvimento/genética; Genes Ligados ao Cromossomo X; Humanos; Lúpus Eritematoso Sistêmico/patologia; Masculino; Inativação do Cromossomo X/genética

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cromossomo X / Mecanismo Genético de Compensação de Dose / RNA Longo não Codificante / Lúpus Eritematoso Sistêmico Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google