From old to new - Repurposing drugs to target mitochondrial energy metabolism in cancer.
Semin Cell Dev Biol
; 98: 211-223, 2020 02.
Article
em En
| MEDLINE
| ID: mdl-31145995
ABSTRACT
Although we have entered the era of personalized medicine and tailored therapies, drugs that target a large variety of cancers regardless of individual patient differences would be a major advance nonetheless. This review article summarizes current concepts and therapeutic opportunities in the area of targeting aerobic mitochondrial energy metabolism in cancer. Old drugs previously used for diseases other than cancer, such as antibiotics and antidiabetics, have the potential to inhibit the growth of various tumor entities. Many drugs are reported to influence mitochondrial metabolism. However, here we consider only those drugs which predominantly inhibit oxidative phosphorylation.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Metabolismo Energético
/
Mitocôndrias
/
Neoplasias
/
Antineoplásicos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article