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Gut Resistome After Oral Antibiotics in Preschool Children in Burkina Faso: A Randomized, Controlled Trial.
Oldenburg, Catherine E; Hinterwirth, Armin; Sié, Ali; Coulibaly, Boubacar; Ouermi, Lucienne; Dah, Clarisse; Tapsoba, Charlemagne; Cummings, Susie L; Zhong, Lina; Chen, Cindi; Sarkar, Samarpita; Bärnighausen, Till; Lietman, Thomas M; Keenan, Jeremy D; Doan, Thuy.
Afiliação
  • Oldenburg CE; Francis I Proctor Foundation, University of California, San Francisco.
  • Hinterwirth A; Department of Ophthalmology, University of California, San Francisco.
  • Sié A; Department of Epidemiology and Biostatistics, University of California, San Francisco.
  • Coulibaly B; Francis I Proctor Foundation, University of California, San Francisco.
  • Ouermi L; Centre de Recherche en Sante de Nouna, Burkina Faso.
  • Dah C; Centre de Recherche en Sante de Nouna, Burkina Faso.
  • Tapsoba C; Centre de Recherche en Sante de Nouna, Burkina Faso.
  • Cummings SL; Centre de Recherche en Sante de Nouna, Burkina Faso.
  • Zhong L; Centre de Recherche en Sante de Nouna, Burkina Faso.
  • Chen C; Francis I Proctor Foundation, University of California, San Francisco.
  • Sarkar S; Francis I Proctor Foundation, University of California, San Francisco.
  • Bärnighausen T; Francis I Proctor Foundation, University of California, San Francisco.
  • Lietman TM; Francis I Proctor Foundation, University of California, San Francisco.
  • Keenan JD; Heidelberg Institute of Global Health, Medical Faculty and University Hospital, University of Heidelberg, Germany.
  • Doan T; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Clin Infect Dis ; 70(3): 525-527, 2020 01 16.
Article em En | MEDLINE | ID: mdl-31149703
We evaluated the effect of systemic antibiotics (azithromycin, amoxicillin, cotrimoxazole, or placebo) on the gut resistome in children aged 6 to 59 months. Azithromycin and cotrimoxazole led to an increase in macrolide and sulfonamide resistance determinants. Resistome expansion can be induced with a single course of antibiotics.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microbioma Gastrointestinal / Antibacterianos Tipo de estudo: Clinical_trials Limite: Child, preschool / Humans / Infant País como assunto: Africa Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microbioma Gastrointestinal / Antibacterianos Tipo de estudo: Clinical_trials Limite: Child, preschool / Humans / Infant País como assunto: Africa Idioma: En Ano de publicação: 2020 Tipo de documento: Article