Engineering cell-cell communication networks: programming multicellular behaviors.
Curr Opin Chem Biol
; 52: 31-38, 2019 10.
Article
em En
| MEDLINE
| ID: mdl-31150899
ABSTRACT
Cell-cell communication governs the biological behaviors of multicellular populations such as developmental and immunological systems. Thanks to intense genetic analytical studies, the molecular components of cell-cell communication pathways have been well identified. We also have been developing synthetic biology tools to control cellular sensing and response systems that enable engineering of new cell-cell communication with design-based regulatory features. Recently, using these molecular backgrounds, synthetic cellular networks have been built and tested to understand the basic principles of multicellular biological behaviors. These approaches will provide new capabilities to control and program desired biological behaviors with engineered cell-cell communication to apply them toward cell-based therapeutics.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Comunicação Celular
/
Biologia Sintética
/
Engenharia Celular
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article