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Effects of current parenteral nutrition treatment on health-related quality of life, physical function, nutritional status, survival and adverse events exclusively in patients with advanced cancer: A systematic literature review.
Tobberup, Randi; Thoresen, Lene; Falkmer, Ursula G; Yilmaz, Mette K; Solheim, Tora S; Balstad, Trude R.
Afiliação
  • Tobberup R; Center for Nutrition and Bowel Disease, Department of Gastroenterology, Aalborg University Hospital, Hobrovej 18-22, 9000, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Fredrik Bajers Vej 5, 9100, Aalborg, Denmark. Electronic address: r.tobberup@rn.dk.
  • Thoresen L; Cancer Clinic, St. Olavs hospital, Trondheim University hospital, Postboks 3250 Torgarden, NO-7006, Trondheim, Norway; National Advisory Unit on Disease-Related Malnutrition, Oslo University Hospital, Sognsvannsveien 9, 0372, Oslo, Norway.
  • Falkmer UG; Department of Clinical Medicine, Aalborg University, Fredrik Bajers Vej 5, 9100, Aalborg, Denmark; Department of Oncology, Clinical Cancer Research Center, Aalborg University Hospital, Hobrovej 18-22, 9000, Aalborg, Denmark.
  • Yilmaz MK; Department of Oncology, Clinical Cancer Research Center, Aalborg University Hospital, Hobrovej 18-22, 9000, Aalborg, Denmark.
  • Solheim TS; Cancer Clinic, St. Olavs hospital, Trondheim University hospital, Postboks 3250 Torgarden, NO-7006, Trondheim, Norway; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, PO Box 8905, NO-7491, Trondheim, Norway
  • Balstad TR; Cancer Clinic, St. Olavs hospital, Trondheim University hospital, Postboks 3250 Torgarden, NO-7006, Trondheim, Norway; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, PO Box 8905, NO-7491, Trondheim, Norway
Crit Rev Oncol Hematol ; 139: 96-107, 2019 Jul.
Article em En | MEDLINE | ID: mdl-31150954
ABSTRACT

BACKGROUND:

The aim was to evaluate the effects of current parenteral nutrition (PN) treatment on clinical outcomes in patients with advanced cancer.

METHODS:

This review was conducted according to the PRISMA guidelines (PROSPERO ID 4201707915).

RESULTS:

Two underpowered randomized controlled trials and six observational studies were retrieved (n = 894 patients). Health-related quality of life and physical function may improve during anti-neoplastic treatment in who PN treatment is the only feeding opportunity, but not necessarily in patients able to feed enterally. Nutritional status may improve in patients regardless of anti-neoplastic treatment and gastrointestinal function. PN treatment was neither superior to fluid in terminal patients nor to dietary counselling in patients able to feed enterally in regards to survival. The total incidence of adverse events was low.

CONCLUSION:

Current PN treatment in patients with advanced cancer is understudied and the level of evidence is weak.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Qualidade de Vida / Atividades Cotidianas / Estado Nutricional / Nutrição Parenteral / Neoplasias / Distúrbios Nutricionais Tipo de estudo: Clinical_trials / Etiology_studies / Guideline / Observational_studies / Prognostic_studies / Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Qualidade de Vida / Atividades Cotidianas / Estado Nutricional / Nutrição Parenteral / Neoplasias / Distúrbios Nutricionais Tipo de estudo: Clinical_trials / Etiology_studies / Guideline / Observational_studies / Prognostic_studies / Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article