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Osteosarcoma in patients over 50 years of age: Multi-institutional retrospective analysis of 104 patients.
Nagano, Akihito; Matsumoto, Seiichi; Kawai, Akira; Okuma, Tomotake; Hiraga, Hiroaki; Matsumoto, Yoshihiro; Nishida, Yoshihiro; Yonemoto, Tsukasa; Hosaka, Masami; Takahashi, Mitsuru; Yoshikawa, Hideki; Kunisada, Toshiyuki; Asanuma, Kunihiro; Naka, Norifumi; Emori, Makoto; Kubo, Tadahiko; Kawashima, Hiroyuki; Kawamoto, Teruya; Yokoyama, Ryohei; Tsukushi, Satoshi; Sato, Kenji; Okamoto, Takeshi; Hiraoka, Koji; Morioka, Hideo; Tanaka, Kazuhiro; Takagi, Tatsuya; Iwamoto, Yukihide; Ozaki, Toshifumi.
Afiliação
  • Nagano A; The Department of Orthopaedic Surgery, Gifu University School of Medicine, 1-1 Yanagido, Gifu, 501-1193, Japan. Electronic address: a-nagano@lucky.odn.ne.jp.
  • Matsumoto S; The Department of Orthopaedic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.
  • Kawai A; The Department of Musculoskeletal Oncology and Rehabilitation, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
  • Okuma T; The Department of Musculoskeletal Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8677, Japan.
  • Hiraga H; The Department of Orthopaedic Surgery, Hokkaido Cancer Center, 4-2-3-54 Kikusui 4-2, 3-54, Shiroishiku, Sapporo, 003-0804, Japan.
  • Matsumoto Y; The Department of Orthopaedic Surgery, Kyushu University, 744 Motooka Nishi-ku, Fukuoka, 819-0395, Japan.
  • Nishida Y; The Department of Orthopedic Surgery, Nagoya University Graduate School and School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
  • Yonemoto T; The Department of Orthopaedic Surgery, Chiba Cancer Center Hospital, 666-2 Nitona-cho Chuo-ku Chiba, 260-8717, Japan.
  • Hosaka M; The Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.
  • Takahashi M; The Department of Orthopaedic Surgery, Shizuoka Cancer Center, 1007 Shimo-Nagakubo, Nagaizumi-Cho, Sunto-Gun, Shizuoka Pref. 411-8777, Japan.
  • Yoshikawa H; The Department of Orthopaedic Surgery, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Kunisada T; The Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
  • Asanuma K; The Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi Tsu, Mie, 5148507, Japan.
  • Naka N; The Department of Orthopaedic Surgery, Osaka International Cancer Center, 3-1-69, Otemae, Chuo-ku, Osaka-shi, Osaka 541-8567, Japan.
  • Emori M; The Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, S1 W17, Chuo-ku, Sapporo, 060-8556, Japan.
  • Kubo T; The Department of Orthopaedic Surgery, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima 734-8553, Japan.
  • Kawashima H; The Department of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, 757 Ichibancho, Asahimachi-dori, Chuo Ward, Niigata City, 951-8510, Japan.
  • Kawamoto T; The Department of Orthopaedic Surgery, Kobe University, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe City, Hyogo Prefecture, 650-0017, Japan.
  • Yokoyama R; The Department of Orthopedic Surgery, National Hospital Organization Kyushu Cancer Center, 3-1-1 Notame, Minami-ku, Fukuoka, 811-1395, Japan.
  • Tsukushi S; The Department of Orthopaedic Surgery, Aichi Cancer Center, 1-1 Kanokoden, Chikusa-ku Nagoya, 464-8681, Japan.
  • Sato K; The Department of Orthopaedic Surgery, Teikyo University, 2-11-1 Kaga Itabashi-ku, Tokyo, 173-8605, Japan.
  • Okamoto T; The Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
  • Hiraoka K; The Department of Orthopaedic Surgery, Kurume University, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan.
  • Morioka H; The Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
  • Tanaka K; The Department of Endoprosthetic Surgery, Oita University, 1-1 Idaigaoka, Hazama-cho, Yufu, Oita 879-5593, Japan.
  • Takagi T; The Department of Orthopaedic Surgery, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
  • Iwamoto Y; Kyushu Rosai Hospital, 1-1 Sonekitamachi, Kokuraminami-ku, Kitakyusyu, 800-0296, Japan.
  • Ozaki T; The Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
J Orthop Sci ; 25(2): 319-323, 2020 Mar.
Article em En | MEDLINE | ID: mdl-31155441
ABSTRACT

BACKGROUND:

Primary osteosarcoma in elderly patients are rare malignant tumors. Its optimal treatment has not yet been determined.

METHODS:

This retrospective study included 104 patients aged >50 years with resectable, non-metastatic osteosarcoma treated by the members of the Bone and Soft Tissue Tumor Study Group of the Japan Clinical Oncology Group. The effects of adjuvant chemotherapy were estimated by comparing outcomes in patients who received surgery plus chemotherapy with those who underwent surgery alone.

RESULTS:

Median age at presentation was 59 years. Neoadjuvant and adjuvant chemotherapy was administered to 83 (79.8%) patients. Patients who underwent surgery plus chemotherapy and those who underwent surgery alone had 5-year overall survival (OS) rates of 68.6% and 71.7%, respectively (p = 0.780), and 5-year relapse free survival (RFS) rates of 48.2% and 43.6%, respectively (p = 0.64). Univariate analysis showed that resection with wide margins was significantly correlated with better prognosis.

CONCLUSIONS:

The addition of chemotherapy to surgery did not improve OS or RFS in patients aged >50 years with resectable, non-metastatic osteosarcoma. Surgery with wide margins was only significantly prognostic of improved survival. The effect of chemotherapy in elderly osteosarcoma patients was unclear.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ósseas / Osteossarcoma / Quimioterapia Adjuvante / Terapia Neoadjuvante Tipo de estudo: Observational_studies / Prognostic_studies Limite: Humans / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ósseas / Osteossarcoma / Quimioterapia Adjuvante / Terapia Neoadjuvante Tipo de estudo: Observational_studies / Prognostic_studies Limite: Humans / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article