Visible-Light-Photosensitized Aryl and Alkyl Decarboxylative Functionalization Reactions.
Angew Chem Int Ed Engl
; 58(31): 10514-10520, 2019 Jul 29.
Article
em En
| MEDLINE
| ID: mdl-31162874
ABSTRACT
Despite significant progress in aliphatic decarboxylation, an efficient and general protocol for radical aromatic decarboxylation has lagged far behind. Herein, we describe a general strategy for rapid access to both aryl and alkyl radicals by photosensitized decarboxylation of the corresponding carboxylic acids esters followed by their successive use in divergent carbon-heteroatom and carbon-carbon bond-forming reactions. Identification of a suitable activator for carboxylic acids is the key to bypass a competing single-electron-transfer mechanism and "switch on" an energy-transfer-mediated homolysis of unsymmetrical σ-bonds for a concerted fragmentation/decarboxylation process.
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MEDLINE
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En
Ano de publicação:
2019
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Article