Stefin A-functionalized liposomes as a system for cathepsins S and L-targeted drug delivery.

Bratovs, Andreja; Kramer, Lovro; Mikhaylov, Georgy; Vasiljeva, Olga; Turk, Boris

Bratovs, Andreja; Kramer, Lovro; Mikhaylov, Georgy; Vasiljeva, Olga; Turk, Boris.

Afiliação

Bratovs A; Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia; Jozef Stefan International Postgraduate School, Jamova 39, Sl-1000 Ljubljana, Slovenia.
Kramer L; Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia.
Mikhaylov G; Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia.
Vasiljeva O; Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia. Electronic address: olga.vasiljeva@gmail.com.
Turk B; Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia; Faculty of Chemistry and Chemical Technology, Vecna Pot 113, University of Ljubljana, SI-1000 Ljubljana, Slovenia. Electronic address: boris.turk@ijs.si.

Biochimie ; 166: 94-102, 2019 Nov.

Article em En | MEDLINE | ID: mdl-31163196

Assuntos

Catepsina L/antagonistas & inibidores; Catepsinas/antagonistas & inibidores; Cistatina A/administração & dosagem; Inibidores de Cisteína Proteinase/administração & dosagem; Portadores de Fármacos; Terapia de Alvo Molecular; Neoplasias/tratamento farmacológico; Animais; Biomarcadores Tumorais/metabolismo; Catepsina L/química; Catepsina L/genética; Catepsinas/química; Catepsinas/genética; Clonagem Molecular; Cistatina A/química; Cistatina A/farmacologia; Inibidores de Cisteína Proteinase/química; Inibidores de Cisteína Proteinase/farmacologia; Escherichia coli/genética; Feminino; Humanos; Lipossomos; Camundongos; Camundongos Congênicos; Pichia/genética; Proteínas Recombinantes/química; Proteínas Recombinantes/genética

Palavras-chave

Cathepsin L; Cathepsin S; Drug delivery; Protease; Tumor microenvironment

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Portadores de Fármacos / Catepsinas / Inibidores de Cisteína Proteinase / Cistatina A / Catepsina L / Terapia de Alvo Molecular / Neoplasias Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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