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Clinicopathological characteristics of ypT0N0 urothelial carcinoma following neoadjuvant chemotherapy and cystectomy.
Magers, Martin J; Kaimakliotis, Hristos Z; Barboza, Marcelo P; Bandali, Elhaam; Adra, Nabil; Koch, Michael O; Cheng, Liang.
Afiliação
  • Magers MJ; Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Kaimakliotis HZ; Department of Urology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Barboza MP; Department of Urology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Bandali E; Department of Urology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Adra N; Divisoin of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Koch MO; Department of Urology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Cheng L; Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana, USA liang_cheng@yahoo.com.
J Clin Pathol ; 72(8): 550-553, 2019 Aug.
Article em En | MEDLINE | ID: mdl-31164444
AIMS: To describe a large tertiary care academic centre's experience with patients who achieve a complete pathological response (ie, ypT0N0) following neoadjuvant chemotherapy (NAC) and radical cystectomy (RC) with emphasis on morphological features present in the RC and clinical outcome. METHODS: 41 patients with ypT0N0 disease following transurethral resection of bladder tumour (TURBT), NAC and RC with available clinical follow-up information were analysed. Slides from all RCs were reviewed to confirm pathological stage and assess for morphological parameters (eg, foreign body giant cell reaction, dystrophic calcification, scar and fat necrosis). RESULTS: With median follow-up of 32.8 months, the recurrence-free survival at 1 and 5 years was 97.4% and 93.5%, while the overall survival at 3 and 5 years was 94.2% and 88.6%, respectively. No patients died of urothelial carcinoma. Stage assigned at TURBT was 1 pTa (2%), 1 pT1 (2%), 38 pT2 (93%) and 1 pT3a (2%). 17 TURBTs demonstrated variant histology, with the majority of these being squamous (65%). The most common morphological features present at RC were scar (100%), foreign body giant cell reaction (80%), chronic inflammation within lamina propria (68%) and dystrophic calcifications (39%). Other morphological features were less common or absent. CONCLUSION: ypT0N0 disease at RC portends an excellent prognosis, regardless of stage or variant histology in the TURBT; scar, foreign body giant cell reaction, chronic inflammation and dystrophic calcifications are often present.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / Carcinoma / Cistectomia / Urotélio / Terapia Neoadjuvante Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / Carcinoma / Cistectomia / Urotélio / Terapia Neoadjuvante Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article