Stress-Induced Changes in the Lipid Microenvironment of ß-(1,3)-d-Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus.

Satish, Shruthi; Jiménez-Ortigosa, Cristina; Zhao, Yanan; Lee, Min Hee; Dolgov, Enriko; Krüger, Thomas; Park, Steven; Denning, David W; Kniemeyer, Olaf; Brakhage, Axel A; Perlin, David S

Satish, Shruthi; Jiménez-Ortigosa, Cristina; Zhao, Yanan; Lee, Min Hee; Dolgov, Enriko; Krüger, Thomas; Park, Steven; Denning, David W; Kniemeyer, Olaf; Brakhage, Axel A; Perlin, David S.

Afiliação

Satish S; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Jiménez-Ortigosa C; Public Health Research Institute, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA.
Zhao Y; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Lee MH; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Dolgov E; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Krüger T; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Park S; Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany.
Denning DW; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Kniemeyer O; National Aspergillosis Centre, Wythenshawe Hospital, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Brakhage AA; Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany.
Perlin DS; Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany.

mBio ; 10(3)2019 06 04.

Article em En | MEDLINE | ID: mdl-31164462

Assuntos

Antifúngicos/farmacologia; Aspergillus fumigatus/efeitos dos fármacos; Farmacorresistência Fúngica/genética; Equinocandinas/farmacologia; Glucosiltransferases/genética; Estresse Fisiológico; Aspergilose/microbiologia; Aspergillus fumigatus/enzimologia; Proteínas Fúngicas/genética; Humanos; Testes de Sensibilidade Microbiana; Estresse Oxidativo; Processamento de Proteína Pós-Traducional; Espécies Reativas de Oxigênio/metabolismo; Esfingosina/análogos & derivados; Esfingosina/metabolismo

Palavras-chave

Aspergillus fumigatus; ROS; antifungal resistance; caspofungin; echinocandins; glucan synthase; glucan synthase inhibitors; lipids

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aspergillus fumigatus / Estresse Fisiológico / Farmacorresistência Fúngica / Equinocandinas / Glucosiltransferases / Antifúngicos Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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