Lineage-dependent role of miR-410-3p as oncomiR in gonadotroph and corticotroph pituitary adenomas or tumor suppressor miR in somatotroph adenomas via MAPK, PTEN/AKT, and STAT3 signaling pathways.

Grzywa, Tomasz M; Klicka, Klaudia; Rak, Beata; Mehlich, Dawid; Garbicz, Filip; Zielinski, Grzegorz; Maksymowicz, Maria; Sajjad, Emir; Wlodarski, Pawel K

Grzywa, Tomasz M; Klicka, Klaudia; Rak, Beata; Mehlich, Dawid; Garbicz, Filip; Zielinski, Grzegorz; Maksymowicz, Maria; Sajjad, Emir; Wlodarski, Pawel K.

Afiliação

Grzywa TM; Center for Preclinical Research, The Department of Methodology, Medical University of Warsaw, 1B Banacha Str., 02-097, Warsaw, Poland.
Klicka K; Center for Preclinical Research, The Department of Histology and Embryology, Medical University of Warsaw, 1B Banacha Str., 02-097, Warsaw, Poland.
Rak B; Center for Preclinical Research, The Department of Methodology, Medical University of Warsaw, 1B Banacha Str., 02-097, Warsaw, Poland.
Mehlich D; Center for Preclinical Research, The Department of Histology and Embryology, Medical University of Warsaw, 1B Banacha Str., 02-097, Warsaw, Poland.
Garbicz F; Center for Preclinical Research, The Department of Methodology, Medical University of Warsaw, 1B Banacha Str., 02-097, Warsaw, Poland. beata.rak@wum.edu.pl.
Zielinski G; Center for Preclinical Research, The Department of Histology and Embryology, Medical University of Warsaw, 1B Banacha Str., 02-097, Warsaw, Poland. beata.rak@wum.edu.pl.
Maksymowicz M; Postgraduate School of Molecular Medicine, Warsaw, Poland. beata.rak@wum.edu.pl.
Sajjad E; The Department of Internal Diseases and Endocrinology, Public Central Teaching Hospital, Medical University of Warsaw, 1A Banacha Str., 02-097, Warsaw, Poland. beata.rak@wum.edu.pl.
Wlodarski PK; Center for Preclinical Research, The Department of Methodology, Medical University of Warsaw, 1B Banacha Str., 02-097, Warsaw, Poland.

Endocrine ; 65(3): 646-655, 2019 09.

Article em En | MEDLINE | ID: mdl-31165412

Assuntos

Adenoma Hipofisário Secretor de ACT/genética; Gonadotropinas/metabolismo; Adenoma Hipofisário Secretor de Hormônio do Crescimento/genética; MicroRNAs/genética; Neoplasias Hipofisárias/genética; Transdução de Sinais/genética; Linhagem Celular Tumoral; Proliferação de Células; Ciclinas/biossíntese; Ciclinas/genética; Adenoma Hipofisário Secretor de Hormônio do Crescimento/metabolismo; Humanos; Proteínas Quinases Ativadas por Mitógeno/genética; Invasividade Neoplásica/genética; Proteína Oncogênica v-akt/genética; PTEN Fosfo-Hidrolase/genética; Neoplasias Hipofisárias/metabolismo; Fator de Transcrição STAT3/genética

Palavras-chave

Invasiveness; MicroRNA; PTEN; Pituitary adenoma; Proliferation; miR-410-3p

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Hipofisárias / Transdução de Sinais / MicroRNAs / Adenoma Hipofisário Secretor de ACT / Adenoma Hipofisário Secretor de Hormônio do Crescimento / Gonadotropinas Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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