Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles.

Cianciaruso, Chiara; Beltraminelli, Tim; Duval, Florent; Nassiri, Sina; Hamelin, Romain; Mozes, André; Gallart-Ayala, Hector; Ceada Torres, Gerardo; Torchia, Bruno; Ries, Carola H; Ivanisevic, Julijana; De Palma, Michele

Cianciaruso, Chiara; Beltraminelli, Tim; Duval, Florent; Nassiri, Sina; Hamelin, Romain; Mozes, André; Gallart-Ayala, Hector; Ceada Torres, Gerardo; Torchia, Bruno; Ries, Carola H; Ivanisevic, Julijana; De Palma, Michele.

Afiliação

Cianciaruso C; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address: chiara.cianciaruso@epfl.ch.
Beltraminelli T; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Duval F; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Nassiri S; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Hamelin R; Proteomics Core Facility, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Mozes A; Flow Cytometry Core Facility, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Gallart-Ayala H; Metabolomics Platform, Faculty of Biology and Medicine, University of Lausanne, 1005 Lausanne, Switzerland.
Ceada Torres G; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Torchia B; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Ries CH; Roche Innovation Center Munich, Roche Pharma Research and Early Development, 82377 Penzberg, Germany.
Ivanisevic J; Metabolomics Platform, Faculty of Biology and Medicine, University of Lausanne, 1005 Lausanne, Switzerland.
De Palma M; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address: michele.depalma@epfl.ch.

Cell Rep ; 27(10): 3062-3080.e11, 2019 06 04.

Article em En | MEDLINE | ID: mdl-31167148

Assuntos

Vesículas Extracelulares/metabolismo; Macrófagos/metabolismo; Animais; Anticorpos/uso terapêutico; Células da Medula Óssea/citologia; Linhagem Celular Tumoral; Proliferação de Células; Neoplasias Colorretais/tratamento farmacológico; Neoplasias Colorretais/metabolismo; Neoplasias Colorretais/patologia; Feminino; Interleucina-4/farmacologia; Lipopolissacarídeos/farmacologia; Macrófagos/citologia; Macrófagos/efeitos dos fármacos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Mapas de Interação de Proteínas; Proteoma/análise; Proteômica; Receptores de Fator Estimulador das Colônias de Granulócitos e Macrófagos/imunologia; Receptores de Fator Estimulador das Colônias de Granulócitos e Macrófagos/metabolismo; Células Th1/citologia; Células Th1/imunologia; Células Th1/metabolismo; Transplante Homólogo

Palavras-chave

T cell response; exosome; extracellular vesicle; inflammation; lipid metabolism; lipidomics; proteomics; tumor microenvironment; tumor-associated macrophage

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vesículas Extracelulares / Macrófagos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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