Endocuff-assisted colonoscopy for surveillance of serrated polyposis syndrome: a multicenter randomized controlled trial.
Endoscopy
; 51(7): 637-645, 2019 07.
Article
em En
| MEDLINE
| ID: mdl-31174224
ABSTRACT
BACKGROUND AND STUDY AIMS:
Serrated polyposis syndrome (SPS) is a condition with high risk for colorectal cancer. The Endocuff device has been shown to increase adenoma detection in the general and screening population. We aimed to ascertain whether Endocuff-assisted colonoscopy increases detection of serrated lesions in comparison with standard colonoscopy during the surveillance of patients with SPS.âMETHODS:
In a multicenter randomized controlled study, patients who met SPS criteria I and/or III under surveillance (previous resection of all serrated lesions ≥â4âmm) were consecutively randomly allocated 11 to Endocuff-assisted colonoscopy or standard colonoscopy, performed by expert endoscopists. The main outcome was the mean number of serrated lesions detected per patient.RESULTS:
122 patients (standard colonoscopy nâ=â60; Endocuff-assisted colonoscopy nâ=â62; 59â% men; mean age 60.6 (standard deviation [SD] 7.5) were included at 4 centers. Baseline variables (demographic data, SPS phenotype, colorectal cancer [CRC] history, cumulative polyps, and follow-up), cecal intubation rate, and withdrawal time were similar between groups. There was no statistically significant difference between Endocuff-assisted colonoscopy and standard colonoscopy for the mean number of serrated lesions detected per patient 5.8 (95â% confidence interval [95â%CI] 4.4â-â7.2) and 5.0 (3.9â-â6.1), respectively (Pâ=â0.36). There were also no differences between Endocuff-assisted and standard colonoscopy for detection of sessile serrated lesions (mean number per patient 2.5 [1.3â-â3.6] vs. 2.0 [1.1â-â3.0], Pâ=â0.54) and adenomas (0.9 [0.5â-â1.3] vs. 0.5 [0.3â-â0.7], Pâ=â0.12).CONCLUSION:
Use of Endocuff-assisted colonoscopy did not significantly increase the number of serrated lesion detected per patient during surveillance of SPS.
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Base de dados:
MEDLINE
Assunto principal:
Colonoscopia
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Neoplasias do Colo
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Polipose Adenomatosa do Colo
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Detecção Precoce de Câncer
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
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Screening_studies
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article