Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection.

Shah, Khushbu; Queener, Sherry; Cody, Vivian; Pace, Jim; Gangjee, Aleem

Shah, Khushbu; Queener, Sherry; Cody, Vivian; Pace, Jim; Gangjee, Aleem.

Afiliação

Shah K; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh PA 15282, United States.
Queener S; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Cody V; Hauptman-Woodward Medical Research Institute, 700 Ellicott Street, Buffalo, NY 14203, United States.
Pace J; Hauptman-Woodward Medical Research Institute, 700 Ellicott Street, Buffalo, NY 14203, United States.
Gangjee A; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh PA 15282, United States. Electronic address: gangjee@duq.edu.

Bioorg Med Chem Lett ; 29(15): 1874-1880, 2019 08 01.

Article em En | MEDLINE | ID: mdl-31176699

Assuntos

Antagonistas do Ácido Fólico/uso terapêutico; Pneumocystis carinii/patogenicidade; Pneumocystis/efeitos dos fármacos; Pirimidinas/uso terapêutico; Trimetoprima/uso terapêutico; Antagonistas do Ácido Fólico/farmacologia; Humanos; Modelos Moleculares; Pirimidinas/farmacologia; Relação Estrutura-Atividade; Trimetoprima/farmacologia

Palavras-chave

DHFR; PCP; Pneumocystis jirovecii; Pyrido[3,2-d]pyrimidines

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumocystis / Pirimidinas / Trimetoprima / Pneumocystis carinii / Antagonistas do Ácido Fólico Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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