The improved antiviral activities of amino-modified chitosan derivatives on Newcastle virus.
Drug Chem Toxicol
; 44(4): 335-340, 2021 Jul.
Article
em En
| MEDLINE
| ID: mdl-31179762
ABSTRACT
Chitosan is widely used as a medical material because of its excellent biological activities. However, the low solubility of natural chitosan limited its medicinal activity to some extent. The solubility can be improved by introducing more active groups and lowering molecular weight. Therefore, 6-amine chitosan derivatives were synthesized in this paper since more active groups were introduced to increase the medicinal activity. Those derivatives were characterized by elemental analysis, HPLC, and FT-IR and the antiviral activity was tested by hemagglutination tests. Finally, 6-amine chitosan derivatives improved the antiviral activity, especially after the introduction of bromine ion. When 6-deoxy-6-bromo-N-phthaloyl chitosan was 1 g/L, they reduced the hemagglutination titer of virus to zero. The RT-PCR result showed that the expression level of TNF-α and IFN-ß increased significantly, which indicated that the antiviral activity of amino-modified chitosan worked through the stimulation of immune response.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
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Vírus da Doença de Newcastle
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Quitosana
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Doença de Newcastle
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article