miR-17-92 and miR-106b-25 clusters regulate beta cell mitotic checkpoint and insulin secretion in mice.

Mandelbaum, Amitai D; Kredo-Russo, Sharon; Aronowitz, Danielle; Myers, Nadav; Yanowski, Eran; Klochendler, Agnes; Swisa, Avital; Dor, Yuval; Hornstein, Eran

Mandelbaum, Amitai D; Kredo-Russo, Sharon; Aronowitz, Danielle; Myers, Nadav; Yanowski, Eran; Klochendler, Agnes; Swisa, Avital; Dor, Yuval; Hornstein, Eran.

Afiliação

Mandelbaum AD; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Kredo-Russo S; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Aronowitz D; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Myers N; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Yanowski E; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Klochendler A; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel.
Swisa A; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel.
Dor Y; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel.
Hornstein E; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel. eran.hornstein@weizmann.ac.il.

Diabetologia ; 62(9): 1653-1666, 2019 09.

Article em En | MEDLINE | ID: mdl-31187215

Assuntos

Secreção de Insulina/fisiologia; Células Secretoras de Insulina/metabolismo; MicroRNAs/metabolismo; Animais; Células Cultivadas; Feminino; Citometria de Fluxo; Secreção de Insulina/genética; Masculino; Espectrometria de Massas; Camundongos; MicroRNAs/genética; Mitose/genética; Mitose/fisiologia; Pâncreas/metabolismo

Palavras-chave

Beta cells; Cell cycle; Diabetes; GSIS; Glucose-stimulated insulin secretion; PKA; Protein kinase A; microRNA

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: MicroRNAs / Células Secretoras de Insulina / Secreção de Insulina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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