ALDH1A1 in patient-derived bladder cancer spheroids activates retinoic acid signaling leading to TUBB3 overexpression and tumor progression.

Namekawa, Takeshi; Ikeda, Kazuhiro; Horie-Inoue, Kuniko; Suzuki, Takashi; Okamoto, Koji; Ichikawa, Tomohiko; Yano, Akihiro; Kawakami, Satoru; Inoue, Satoshi

Namekawa, Takeshi; Ikeda, Kazuhiro; Horie-Inoue, Kuniko; Suzuki, Takashi; Okamoto, Koji; Ichikawa, Tomohiko; Yano, Akihiro; Kawakami, Satoru; Inoue, Satoshi.

Afiliação

Namekawa T; Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Japan.
Ikeda K; Department of Urology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Horie-Inoue K; Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Japan.
Suzuki T; Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Japan.
Okamoto K; Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Ichikawa T; Division of Cancer Differentiation, National Cancer Center Hospital, Tokyo, Japan.
Yano A; Department of Urology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Kawakami S; Department of Urology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan.
Inoue S; Department of Urology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan.

Int J Cancer ; 146(4): 1099-1113, 2020 02 15.

Article em En | MEDLINE | ID: mdl-31187490

Assuntos

Família Aldeído Desidrogenase 1/metabolismo; Retinal Desidrogenase/metabolismo; Tubulina (Proteína)/biossíntese; Neoplasias da Bexiga Urinária/metabolismo; Família Aldeído Desidrogenase 1/antagonistas & inibidores; Família Aldeído Desidrogenase 1/genética; Animais; Linhagem Celular Tumoral; Progressão da Doença; Regulação para Baixo; Células HEK293; Xenoenxertos; Humanos; Masculino; Camundongos; Células-Tronco Neoplásicas/metabolismo; Células-Tronco Neoplásicas/patologia; Retinal Desidrogenase/antagonistas & inibidores; Retinal Desidrogenase/genética; Receptor alfa de Ácido Retinoico; Transdução de Sinais; Esferoides Celulares; Tretinoína; Tubulina (Proteína)/genética; Neoplasias da Bexiga Urinária/genética; Neoplasias da Bexiga Urinária/patologia

Palavras-chave

ALDH1A1; TUBB3; bladder cancer; cancer stem-like cells; patient-derived cells; spheroid

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tubulina (Proteína) / Neoplasias da Bexiga Urinária / Retinal Desidrogenase / Família Aldeído Desidrogenase 1 Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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