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Two novel non-holostane type glycosides from the viscera of sea cucumber Apostichopus japonicus.
Zhang, Xuan-Ming; Han, Li-Wen; Sheng, Wen-Long; Li, Xiao-Bin; Zhang, Shan-Shan; Guo, Jing-Lan; Lin, Hou-Wen; Liu, Ke-Chun.
Afiliação
  • Zhang XM; Key Laboratory for Drug Screening Technology & Key Laboratory for Biosensors, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
  • Han LW; Key Laboratory for Drug Screening Technology & Key Laboratory for Biosensors, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
  • Sheng WL; Key Laboratory for Drug Screening Technology & Key Laboratory for Biosensors, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
  • Li XB; Key Laboratory for Drug Screening Technology & Key Laboratory for Biosensors, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
  • Zhang SS; Key Laboratory for Drug Screening Technology & Key Laboratory for Biosensors, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
  • Guo JL; Key Laboratory for Drug Screening Technology & Key Laboratory for Biosensors, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
  • Lin HW; Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
  • Liu KC; Key Laboratory for Drug Screening Technology & Key Laboratory for Biosensors, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
J Asian Nat Prod Res ; 22(4): 329-337, 2020 Apr.
Article em En | MEDLINE | ID: mdl-31190553
ABSTRACT
Two novel glycosides, apostichoposide A1 (1) and B1 (2), were isolated from the viscera of Chinese sea cucumbers (Apostichopus japonicus, Selenka) collected in the Bohai sea. Both the isolated glycosides were characterized by non-holostane type aglycones having 18(16)-lactone and 7(8)-double bond. Cytotoxic activities of the two compounds were evaluated against three human cancer cell lines. Compound 1 had adequate cytotoxic activity against MGC-803 and PC-3M cell lines. Our results indicated that glycosides present in A. japonicus viscera are an important high value resource for biotechnological applications.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pepinos-do-Mar / Triterpenos / Stichopus Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pepinos-do-Mar / Triterpenos / Stichopus Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article