Gab2 promotes cancer stem cell like properties and metastatic growth of ovarian cancer via downregulation of miR-200c.

Fang, Zenghui; Li, Tong; Chen, Wanzhou; Wu, Du; Qin, Yaqian; Liu, Min; Wu, Guang; He, Licai; Li, Hongzhi; Gu, Haihua

Fang, Zenghui; Li, Tong; Chen, Wanzhou; Wu, Du; Qin, Yaqian; Liu, Min; Wu, Guang; He, Licai; Li, Hongzhi; Gu, Haihua.

Afiliação

Fang Z; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China.
Li T; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China.
Chen W; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China.
Wu D; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China.
Qin Y; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China.
Liu M; Department of Orthopedics, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325200, China.
Wu G; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China.
He L; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China.
Li H; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: lhz@wmu.edu.cn.
Gu H; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: haihuagu@wmu.edu.cn.

Exp Cell Res ; 382(1): 111462, 2019 09 01.

Article em En | MEDLINE | ID: mdl-31194976

Assuntos

Proteínas Adaptadoras de Transdução de Sinal/fisiologia; Regulação Neoplásica da Expressão Gênica; MicroRNAs/fisiologia; Proteínas de Neoplasias/fisiologia; Neoplasias Ovarianas/genética; RNA Neoplásico/fisiologia; Animais; Movimento Celular; Regulação para Baixo; Feminino; Xenoenxertos; Humanos; Receptores de Hialuronatos/antagonistas & inibidores; Receptores de Hialuronatos/biossíntese; Receptores de Hialuronatos/genética; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; MicroRNAs/genética; Invasividade Neoplásica; Metástase Neoplásica; Células-Tronco Neoplásicas/metabolismo; Células-Tronco Neoplásicas/patologia; Neoplasias Ovarianas/metabolismo; Neoplasias Ovarianas/patologia; Fosfatidilinositol 3-Quinases/fisiologia; Interferência de RNA; RNA Neoplásico/genética; RNA Interferente Pequeno/genética; RNA Interferente Pequeno/farmacologia

Palavras-chave

Cancer stem cells; Gab2; Ovarian cancer; PI3K; miR-200c

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / RNA Neoplásico / Regulação Neoplásica da Expressão Gênica / MicroRNAs / Proteínas Adaptadoras de Transdução de Sinal / Proteínas de Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google