Moderate- to high-intensity exercise does not modify cortical ß-amyloid in Alzheimer's disease.
Alzheimers Dement (N Y)
; 5: 208-215, 2019.
Article
em En
| MEDLINE
| ID: mdl-31198839
ABSTRACT
INTRODUCTION:
Animal models of Alzheimer's disease show that exercise may modify ß-amyloid (Aß) deposition. We examined the effect of a 16-week exercise intervention on cortical Aß in patients with mild-to-moderate Alzheimer's disease.METHODS:
Thirty-six patients with Alzheimer's disease were randomized to either one hour of aerobic exercise three times weekly for 16 weeks or usual care. Pre and post intervention, 11Carbon-Pittsburgh compound B positron emission tomography was carried out to assess cortical Aß, and quantified using standardized uptake value rations (SUVRs).RESULTS:
The intervention showed no effect on follow-up SUVRs in a covariance analysis with group allocation, baseline intervention SUVR, age, sex, and baseline Mini-Mental State Examination as predictors. Change in SUVRs did not correlate with changes in measures of physical or aerobic fitness.DISCUSSION:
The present findings do not support an effect of exercise on Aß. However, the relatively short intervention period may account for a lack of efficacy. Further studies should test earlier and longer interventions.
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Base de dados:
MEDLINE
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article