Synaptic properties of newly generated granule cells support sparse coding in the adult hippocampus.

ABSTRACT

In the adult hippocampus new neurons are continuously generated throughout life and integrate into the existing network via the formation of thousands of new synapses. Adult-born granule cells are known to improve learning and memory at about 3-6 weeks post mitosis by enhancing the brains ability to discriminate similar memory items. However, the underlying mechanisms are still controversial. Here we review the distinct functional properties of the newborn young neurons, including enhanced excitability, reduced GABAergic inhibition, NMDA-receptor dependent electrogenesis and enhanced synaptic plasticity. Although these cellular properties provide a competitive advantage for synapse formation, they do not generate 'hyperactivity' of young neurons. By contrast, in vivo evidence from immediate early gene expression and calcium imaging indicates that young neurons show sparse activity during learning. Similarly, in vitro data show a low number of high-impact synapses, leading to activation young cells by distinct subsets of afferent fibers with minimal overlap. Overall, the enhanced excitability of young cells does not generate hyperactivity but rather counterbalance the low number of excitatory input synapses. Finally, sparse coding in young neurons has been shown to be crucial for neurogenesis-dependent improvement of learning behavior. Taken together, converging evidence from cell physiology and behavioral studies suggests a mechanism that can explain the beneficial effects of adult neurogenesis on brain function.