Is atopy a risk indicator of chronic obstructive pulmonary disease in dairy farmers?
Respir Res
; 20(1): 124, 2019 Jun 17.
Article
em En
| MEDLINE
| ID: mdl-31208466
ABSTRACT
Allergic mechanisms related to environmental and occupational exposure have been suggested to contribute to the development of chronic obstructive pulmonary disease (COPD). OBJECTIVES:
To investigate the relationships between atopy markers, persistent airflow limitation (PAL) and occupational exposure in dairy farmers.METHODS:
Clinical and biological (total IgE and 21 allergen specific IgE) markers of atopy were assessed in 101 dairy farmers with PAL (DF-PAL), 85 non-farmers with PAL (NF-PAL) (both groups were prospectively included from a screening program performed between 2011 and 2015), and matched controls, i.e. 98 farmers without PAL (DF-controls) and 89 non-farming subjects without PAL (NF-controls). Occupational exposure in farmers was estimated using a validated questionnaire.RESULTS:
Prevalence of allergy history was significantly higher in DF-PAL and in NF-PAL than in controls. Polysensitization, and sensitization to seasonal and food allergens were more frequent in DF-PAL than in DF-controls, respectively 13.8% vs 1% (adjusted odds ratio (aOR) 17.5 (2.2-134), 11.9% vs 3.1% (aOR 4.4 (1.2-7.2) and 16.8% vs 4.1% (aOR 5.2 (1.7-7.2)). The prevalence of atopy markers was similar between NF-PAL patients and NF-controls.CONCLUSIONS:
PAL in farmers is associated with a high rate of markers of atopy, supporting atopy as a risk indicator. Clinical trial registered with ClinicalTrials.gov (NCT02540408).Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Exposição Ocupacional
/
Doença Pulmonar Obstrutiva Crônica
/
Indústria de Laticínios
/
Doenças dos Trabalhadores Agrícolas
/
Fazendeiros
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article