A small-molecule inhibitor of C5 complement protein.
Nat Chem Biol
; 15(7): 666-668, 2019 07.
Article
em En
| MEDLINE
| ID: mdl-31209353
ABSTRACT
The complement pathway is an important part of the immune system, and uncontrolled activation is implicated in many diseases. The human complement component 5 protein (C5) is a validated drug target within the complement pathway, as an anti-C5 antibody (Soliris) is an approved therapy for paroxysmal nocturnal hemoglobinuria. Here, we report the identification, optimization and mechanism of action for the first small-molecule inhibitor of C5 complement protein.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complemento C5
/
Bibliotecas de Moléculas Pequenas
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article