Silencing cryptic specialized metabolism in <i>Streptomyces</i> by the nucleoid-associated protein Lsr2.

Gehrke, Emma J; Zhang, Xiafei; Pimentel-Elardo, Sheila M; Johnson, Andrew R; Rees, Christiaan A; Jones, Stephanie E; Gehrke, Sebastian S; Turvey, Sonya; Boursalie, Suzanne; Hill, Jane E; Carlson, Erin E; Nodwell, Justin R; Elliot, Marie A

Silencing cryptic specialized metabolism in Streptomyces by the nucleoid-associated protein Lsr2.

Gehrke, Emma J; Zhang, Xiafei; Pimentel-Elardo, Sheila M; Johnson, Andrew R; Rees, Christiaan A; Jones, Stephanie E; Gehrke, Sebastian S; Turvey, Sonya; Boursalie, Suzanne; Hill, Jane E; Carlson, Erin E; Nodwell, Justin R; Elliot, Marie A.

Afiliação

Gehrke EJ; Department of Biology, McMaster University, Hamilton, Canada.
Zhang X; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Canada.
Pimentel-Elardo SM; Department of Biology, McMaster University, Hamilton, Canada.
Johnson AR; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Canada.
Rees CA; Department of Biochemistry, University of Toronto, Toronto, Canada.
Jones SE; Department of Chemistry, Indiana University, Bloomington, United States.
Hindra; Geisel School of Medicine and Thayer School of Engineering, Dartmouth College, Hanover, United States.
Gehrke SS; Department of Biology, McMaster University, Hamilton, Canada.
Turvey S; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Canada.
Boursalie S; Department of Biology, McMaster University, Hamilton, Canada.
Hill JE; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Canada.
Carlson EE; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.
Nodwell JR; Department of Biology, McMaster University, Hamilton, Canada.
Elliot MA; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Canada.

Elife ; 82019 06 19.

Article em En | MEDLINE | ID: mdl-31215866

Assuntos

Proteínas de Bactérias/metabolismo; Núcleo Celular/metabolismo; Streptomyces/metabolismo; Antibacterianos/biossíntese; Proteínas de Bactérias/genética; Sítios de Ligação; Vias Biossintéticas/genética; Cromossomos Bacterianos/genética; Regulação Bacteriana da Expressão Gênica; Transferência Genética Horizontal/genética; Genes Bacterianos; Metaboloma/genética; Mutação/genética; Fenótipo; Streptomyces/genética; Volatilização

Palavras-chave

DNA-binding protein; Streptomyces; antibiotics; infectious disease; microbiology; nucleoid-associated protein; repressor; specialized metabolism

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Streptomyces / Proteínas de Bactérias / Núcleo Celular Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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