Simultaneous quantification of ligustilide, dl-3-n-butylphthalide and senkyunolide A in rat plasma by GC-MS and its application to comparative pharmacokinetic studies of Rhizoma Chuanxiong extract alone and Baizhi Chuanxiong Decoction.

Wang, Qinhui; Yan, Tao; Jiang, Wei; Hu, Na; Zhang, Song; Yang, Peng; Zhang, Wenjuan; Shi, Lei; Liu, Linna

Wang, Qinhui; Yan, Tao; Jiang, Wei; Hu, Na; Zhang, Song; Yang, Peng; Zhang, Wenjuan; Shi, Lei; Liu, Linna.

Afiliação

Wang Q; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China.
Yan T; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China.
Jiang W; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China.
Hu N; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China.
Zhang S; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China.
Yang P; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China.
Zhang W; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China.
Shi L; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China.
Liu L; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China.

Biomed Chromatogr ; 33(10): e4625, 2019 Oct.

Article em En | MEDLINE | ID: mdl-31222844

Assuntos

4-Butirolactona/análogos & derivados; Benzofuranos/sangue; Medicamentos de Ervas Chinesas; Cromatografia Gasosa-Espectrometria de Massas/métodos; 4-Butirolactona/sangue; 4-Butirolactona/química; 4-Butirolactona/farmacocinética; Administração Oral; Animais; Benzofuranos/química; Benzofuranos/farmacocinética; Medicamentos de Ervas Chinesas/administração & dosagem; Medicamentos de Ervas Chinesas/farmacocinética; Limite de Detecção; Modelos Lineares; Masculino; Ratos; Ratos Sprague-Dawley; Reprodutibilidade dos Testes

Palavras-chave

GC-MS; dl-3-n-butylphthalide; ligustilide; pharmacokinetics; senkyunolide A

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzofuranos / 4-Butirolactona / Medicamentos de Ervas Chinesas / Cromatografia Gasosa-Espectrometria de Massas Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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