Total Synthesis of the Proposed Structure of Penasulfate A: l-Arabinose as a Source of Chirality.

ABSTRACT

The total synthesis of putative penasulfate A was effectively achieved by a convergent strategy with a longest linear sequence of 14 steps and overall yield of 8.6%. The highlights of our strategy involved an E-selective olefin cross-metathesis, Suzuki cross-coupling, and a copper(I)-catalyzed coupling reaction.