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Dopamine-functionalized cyclodextrins: modification of reduced graphene oxide based electrodes and sensing of folic acid in human serum.
Chekin, Fereshteh; Mishyn, Vladyslav; Barras, Alexandre; Lyskawa, Joel; Ye, Ran; Melinte, Sorin; Woisel, Patrice; Boukherroub, Rabah; Szunerits, Sabine.
Afiliação
  • Chekin F; Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University, Amol, 46178-678, Iran. fchekin@yahoo.com.
  • Mishyn V; Université de Lille, CNRS, Centrale Lille, ISEN, Université de Valenciennes, UMR 8520-IEMN, 59000, Lille, France. fchekin@yahoo.com.
  • Barras A; Université de Lille, CNRS, Centrale Lille, ISEN, Université de Valenciennes, UMR 8520-IEMN, 59000, Lille, France.
  • Lyskawa J; Université de Lille, CNRS, Centrale Lille, ISEN, Université de Valenciennes, UMR 8520-IEMN, 59000, Lille, France.
  • Ye R; Unité des Matériaux et Transformations (UMR 8207), Equipe Ingénierie des Systèmes Polymères, Université de Lille, 59655, Villeneuve d'Ascq Cedex, France.
  • Melinte S; Institute of Information and Communication Technologies, Electronics and Applied Mathematics, Université catholique de Louvain, 1348, Louvain-la-Neuve, Belgium.
  • Woisel P; Institute of Information and Communication Technologies, Electronics and Applied Mathematics, Université catholique de Louvain, 1348, Louvain-la-Neuve, Belgium.
  • Boukherroub R; Unité des Matériaux et Transformations (UMR 8207), Equipe Ingénierie des Systèmes Polymères, Université de Lille, 59655, Villeneuve d'Ascq Cedex, France.
  • Szunerits S; Université de Lille, CNRS, Centrale Lille, ISEN, Université de Valenciennes, UMR 8520-IEMN, 59000, Lille, France.
Anal Bioanal Chem ; 411(20): 5149-5157, 2019 Aug.
Article em En | MEDLINE | ID: mdl-31250067
A mandatory step in any sensor fabrication is the introduction of analyte-specific recognition elements to the transducer surface. In this study, the possibility to anchor ß-cyclodextrin-modified dopamine to a reduced graphene oxide based electrochemical transducer for the sensitive and selective sensing of folic acid is demonstrated. The sensor displays good electrocatalytic activity toward the oxidation of folic acid. The strong affinity of the surface-confined ß-cyclodextrin for folic acid, together with favorable electron transfer characteristics, resulted in a sensor with a detection limit of 1 nM for folic acid and a linear response up to 10 µM. Testing of the sensor on serum samples from healthy individuals and patients diagnosed with folic acid deficiency validated the sensing capability. Graphical abstract.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dopamina / Ciclodextrinas / Eletrodos / Ácido Fólico / Grafite Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dopamina / Ciclodextrinas / Eletrodos / Ácido Fólico / Grafite Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article