Bovine leukemia virus detected in the breast tissue and blood of Iranian women.
Microb Pathog
; 135: 103566, 2019 Oct.
Article
em En
| MEDLINE
| ID: mdl-31252065
ABSTRACT
BACKGROUND:
Breast cancer is one of the most common cancers in the world particularly among Iranian women. Bovine leukemia virus (BLV) is an enzootic, exogenous, and oncogenic retrovirus that causes B-cell leukosis in 1-5% of infected cattle. The current study aimed at evaluating the correlation between BLV infection and breast cancer in an Iranian population. MATERIALS AND TECHNIQUES A total of 400 samples including 200 breast cancer-suspected tissue samples and 200 blood samples of women without breast cancer, were collected from July 2017 to October 2018 from women referred to two general hospitals in Qom Province, Iran. The nested PCR technique was performed to determine the presence of tax and gag gene of BLV in the collected samples.RESULTS:
Out of 200 breast cancer-suspected tissue samples, 172 samples were malignant in terms of pathology. Other samples were reported as non-malignant and non-tumor. Based on nested PCR technique, tax and gag genes of BLV were detected in 30% and 8% of breast cancer-suspected tissue samples, respectively. The frequency of BLV in blood samples collected from women without breast cancer was 16.5% (33/200).CONCLUSION:
It seems that human breast cancer and BLV infection in cattle could be associated using nested PCR technique.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sangue
/
Mama
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Infecções por Deltaretrovirus
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Vírus da Leucemia Bovina
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Middle aged
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article