Fibroblast growth factor 21 enhances angiogenesis and wound healing of human brain microvascular endothelial cells by activating PPARÎ³.

Huang, Wenting; Shao, Mingjie; Liu, Huan; Chen, Jun; Hu, Jian; Zhu, Liyun; Liu, Fei; Wang, Dongxue; Zou, Yuchi; Xiong, Ye; Wang, Xue

Huang, Wenting; Shao, Mingjie; Liu, Huan; Chen, Jun; Hu, Jian; Zhu, Liyun; Liu, Fei; Wang, Dongxue; Zou, Yuchi; Xiong, Ye; Wang, Xue.

Afiliação

Huang W; School of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Shao M; School of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Liu H; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Chen J; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Hu J; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Zhu L; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Liu F; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Wang D; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Zou Y; The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 315020, China.
Xiong Y; The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 315020, China. Electronic address: xiongye2310@163.com.
Wang X; School of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China. Electronic address: xinyuw001@163.com.

J Pharmacol Sci ; 140(2): 120-127, 2019 Jun.

Article em En | MEDLINE | ID: mdl-31255518

Assuntos

Encéfalo/irrigação sanguínea; Células Endoteliais/fisiologia; Fatores de Crescimento de Fibroblastos/fisiologia; Microvasos/citologia; Neovascularização Fisiológica/genética; PPAR gama/metabolismo; Cicatrização/genética; Lesões Encefálicas/genética; Lesões Encefálicas/terapia; Células Cultivadas; Fatores de Crescimento de Fibroblastos/uso terapêutico; Humanos; Proteínas Klotho; Proteínas de Membrana/metabolismo; Terapia de Alvo Molecular; Óxido Nítrico Sintase Tipo III/metabolismo; Receptor Tipo 1 de Fator de Crescimento de Fibroblastos/metabolismo; Proteínas Recombinantes

Palavras-chave

Angiogenesis; FGF21; FGF21/FGFR1/ß-klotho complex; PPARÎ³; Wound healing

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cicatrização / Encéfalo / Neovascularização Fisiológica / Células Endoteliais / PPAR gama / Microvasos / Fatores de Crescimento de Fibroblastos Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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