Development of a specific fragment pattern-based quadrupole-Orbitrap mass spectrometry method to screen adulterated products of phosphodiesterase-5 inhibitors and their analogues.

Lee, Ji Hyun; Park, Han Na; Park, Seongsoo; Lee, Yong-Moon; Kang, Hoil

Lee, Ji Hyun; Park, Han Na; Park, Seongsoo; Lee, Yong-Moon; Kang, Hoil.

Afiliação

Lee JH; Division of Advanced Analysis, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju-si, Chungcheongbuk-do 28159, Republic of Korea.
Park HN; Division of Advanced Analysis, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju-si, Chungcheongbuk-do 28159, Republic of Korea.
Park S; Division of Advanced Analysis, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju-si, Chungcheongbuk-do 28159, Republic of Korea.
Lee YM; College of Pharmacy, Chungbuk National University, Cheongju-si, Chungcheongbuk-do 28159, Republic of Korea. Electronic address: ymleefn@chungbuk.ac.kr.
Kang H; Division of Advanced Analysis, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju-si, Chungcheongbuk-do 28159, Republic of Korea. Electronic address: kanghi79@gmail.com.

Sci Justice ; 59(4): 433-441, 2019 07.

Article em En | MEDLINE | ID: mdl-31256815

Assuntos

Cromatografia Líquida de Alta Pressão/métodos; Medicamentos Falsificados; Espectrometria de Massas/métodos; Inibidores da Fosfodiesterase 5/química; Vasodilatadores/química; Suplementos Nutricionais; Contaminação de Medicamentos; Contaminação de Alimentos; Citrato de Sildenafila/análogos & derivados; Tadalafila/análogos & derivados; Dicloridrato de Vardenafila/análogos & derivados

Palavras-chave

Adulterated product; Fragmentation pathways; PDE-5i analogue; Q-Orbitrap-MS; Screening; Validation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Espectrometria de Massas / Vasodilatadores / Cromatografia Líquida de Alta Pressão / Medicamentos Falsificados / Inibidores da Fosfodiesterase 5 Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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