MG53 attenuates lipopolysaccharide-induced neurotoxicity and neuroinflammation via inhibiting TLR4/NF-&#954;B pathway in vitro and in vivo.

Guan, Fangxia; Zhou, Xinkui; Li, Peng; Wang, Yaping; Liu, Ming; Li, Fangfang; Cui, Yuanbo; Huang, Tuanjie; Yao, Minghao; Zhang, Yanting; Ma, Jianjie; Ma, Shanshan

MG53 attenuates lipopolysaccharide-induced neurotoxicity and neuroinflammation via inhibiting TLR4/NF-κB pathway in vitro and in vivo.

Guan, Fangxia; Zhou, Xinkui; Li, Peng; Wang, Yaping; Liu, Ming; Li, Fangfang; Cui, Yuanbo; Huang, Tuanjie; Yao, Minghao; Zhang, Yanting; Ma, Jianjie; Ma, Shanshan.

Afiliação

Guan F; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China; Henan Provincial People's Hospital, Zhengzhou 450003, Henan, China.
Zhou X; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China.
Li P; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China; Clinical Laboratory, Zhumadian Hospital of Traditional Chinese Medicine, Zhumadian 463000, Henan, China.
Wang Y; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China.
Liu M; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China.
Li F; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China.
Cui Y; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China.
Huang T; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China.
Yao M; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China.
Zhang Y; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China.
Ma J; Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA. Electronic address: Jianjie.Ma@osumc.edu.
Ma S; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China. Electronic address: mss@zzu.edu.cn.

Prog Neuropsychopharmacol Biol Psychiatry ; 95: 109684, 2019 12 20.

Article em En | MEDLINE | ID: mdl-31260721

Assuntos

Inflamação/metabolismo; Lipopolissacarídeos/farmacologia; Neurônios/efeitos dos fármacos; Fármacos Neuroprotetores/farmacologia; Transdução de Sinais/efeitos dos fármacos; Proteínas com Motivo Tripartido/farmacologia; Animais; Apoptose/efeitos dos fármacos; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Linhagem Celular; Hipocampo/efeitos dos fármacos; Hipocampo/metabolismo; Aprendizagem em Labirinto/efeitos dos fármacos; Camundongos; NF-kappa B/metabolismo; Neurônios/metabolismo; Transdução de Sinais/fisiologia; Receptor 4 Toll-Like/metabolismo

Palavras-chave

Cognitive impairment; Lipopolysaccharide; MG53 protein; Neurotoxicity; TLR4/NF-κB pathway

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Lipopolissacarídeos / Fármacos Neuroprotetores / Proteínas com Motivo Tripartido / Inflamação / Neurônios Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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