Caveolin-1 knockdown increases the therapeutic sensitivity of lung cancer to cisplatin-induced apoptosis by repressing Parkin-related mitophagy and activating the ROCK1 pathway.

Liu, Yi; Fu, Yili; Hu, Xianoxing; Chen, Shuo; Miao, Jinbai; Wang, Yang; Zhou, Ying; Zhang, Yuan

Liu, Yi; Fu, Yili; Hu, Xianoxing; Chen, Shuo; Miao, Jinbai; Wang, Yang; Zhou, Ying; Zhang, Yuan.

Afiliação

Liu Y; Department of Thoracic Surgery, Beijing Chaoyang Hospital, Beijing, Chaoyang, China.
Fu Y; Department of Thoracic Surgery, Beijing Chaoyang Hospital, Beijing, Chaoyang, China.
Hu X; Department of Thoracic Surgery, Beijing Chaoyang Hospital, Beijing, Chaoyang, China.
Chen S; Department of Thoracic Surgery, Beijing Chaoyang Hospital, Beijing, Chaoyang, China.
Miao J; Department of Thoracic Surgery, Beijing Chaoyang Hospital, Beijing, Chaoyang, China.
Wang Y; Department of Thoracic Surgery, Beijing Chaoyang Hospital, Beijing, Chaoyang, China.
Zhou Y; Department of Pulmonary and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, Yangpu, China.
Zhang Y; Department of Pulmonary and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, Yangpu, China.

J Cell Physiol ; 235(2): 1197-1208, 2020 02.

Article em En | MEDLINE | ID: mdl-31270811

Assuntos

Caveolina 1/metabolismo; Cisplatino/farmacologia; Regulação da Expressão Gênica/efeitos dos fármacos; Neoplasias Pulmonares/tratamento farmacológico; Ubiquitina-Proteína Ligases/metabolismo; Quinases Associadas a rho/metabolismo; Células A549; Amidas/farmacologia; Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Caveolina 1/genética; Humanos; Neoplasias Pulmonares/metabolismo; Mitofagia/efeitos dos fármacos; Mitofagia/fisiologia; Piridinas/farmacologia; RNA Interferente Pequeno; Espécies Reativas de Oxigênio; Ubiquitina-Proteína Ligases/genética; Quinases Associadas a rho/genética

Palavras-chave

Cav-1; ROCK1; apoptosis; lung cancer; mitophagy

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica / Cisplatino / Ubiquitina-Proteína Ligases / Caveolina 1 / Quinases Associadas a rho / Neoplasias Pulmonares Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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