NT-pro-BNP: A novel predictor of stroke risk after transient ischemic attack.
Int J Cardiol
; 298: 93-97, 2020 01 01.
Article
em En
| MEDLINE
| ID: mdl-31272739
ABSTRACT
BACKGROUND:
Elevated levels of B-type natriuretic peptide (BNP) and NT-pro-BNP can predict an increased risk of cardiovascular events and ischemic stroke. The limited reliability to predict the risk of stroke after a transient ischemic attack (TIA) justifies the objective of our study to determine the role of NT-pro-BNP in patients with TIAs.METHODS:
From our prospective stroke registry, we performed a retrospective study in all patients with the diagnosis of TIA admitted to the Stroke Unit of our Hospital between January 2008 and March 2018. NT-pro-BNP was determined in the first hours after TIA. The endpoint was the development of stroke during the follow-up.RESULTS:
381 patients were included. Mean time of follow-up was 36.8 (±16.4) months. 224 patients were hospitalized due to a stroke during the follow-up, and 157 were not. NT-pro-BNP serum levels were higher in patients who suffered a stroke compared to those who did not (pâ¯âªâ¯0.001). We also found greater levels of this marker the earlier the stroke happened (pâ¯=â¯0.024). A cut-off point of 800â¯pg/mL of NT-pro-BNP predicted a stroke with a sensitivity of 64% and a specificity of 79% (pâ¯âªâ¯0.001), and was independently associated with higher risk of stroke after a TIA (OR 6.65, pâ¯âªâ¯0.001). This association persisted for different etiopathogenic TIA groups (cardioembolic OR 26.12, pâ¯âªâ¯0.001; undetermined OR 4.87, pâ¯=â¯0.006; atherothrombotic OR 1.67, pâ¯=â¯0.044).CONCLUSIONS:
The early determination of NT-pro-BNP is a simple and very useful alternative to predict the prognosis after TIA regardless of the etiopathogenesis of the TIA.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
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Ataque Isquêmico Transitório
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Peptídeo Natriurético Encefálico
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Acidente Vascular Cerebral
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article