Vascular Protection and Decongestion Without Renin-Angiotensin-Aldosterone System Stimulation Mediated by a Novel Dual-Acting Vasopressin V1a/V2 Receptor Antagonist.

Kolkhof, Peter; Pook, Elisabeth; Pavkovic, Mira; Kretschmer, Axel; Buchmüller, Anja; Tinel, Hanna; Delbeck, Martina; Mondritzki, Thomas; Wasnaire, Pierre; Dinh, Wilfried; Truebel, Hubert; Hüser, Jörg; Schmeck, Carsten

Kolkhof, Peter; Pook, Elisabeth; Pavkovic, Mira; Kretschmer, Axel; Buchmüller, Anja; Tinel, Hanna; Delbeck, Martina; Mondritzki, Thomas; Wasnaire, Pierre; Dinh, Wilfried; Truebel, Hubert; Hüser, Jörg; Schmeck, Carsten.

Afiliação

Kolkhof P; Department of Cardiovascular Research, BAYER AG, Research and Development.
Pook E; Department of Lead Discovery, BAYER AG, Research and Development.
Pavkovic M; Department of Biomarker Research, BAYER AG, Research and Development.
Kretschmer A; Department of Biomarker Research, BAYER AG, Research and Development.
Buchmüller A; Department of Cardiovascular Research, BAYER AG, Research and Development.
Tinel H; Department of Cardiovascular Research, BAYER AG, Research and Development.
Delbeck M; Department of Cardiovascular Research, BAYER AG, Research and Development.
Mondritzki T; Department of Cardiovascular Research, BAYER AG, Research and Development.
Wasnaire P; Center for Clinical Medicine, University Faculty of Health, University of Witten Herdecke, Witten, Germany.
Dinh W; Department of Medicinal Chemistry, BAYER AG, Research and Development.
Truebel H; Department of Clinical Science, BAYER AG, Research and Development, Wuppertal, Germany.
Hüser J; Center for Clinical Medicine, University Faculty of Health, University of Witten Herdecke, Witten, Germany.
Schmeck C; Department of Clinical Science, BAYER AG, Research and Development, Wuppertal, Germany.

J Cardiovasc Pharmacol ; 74(1): 44-52, 2019 07.

Article em En | MEDLINE | ID: mdl-31274842

Assuntos

Antagonistas dos Receptores de Hormônios Antidiuréticos/farmacologia; Insuficiência Cardíaca/tratamento farmacológico; Receptores de Vasopressinas/efeitos dos fármacos; Animais; Aorta/efeitos dos fármacos; Aorta/metabolismo; Pressão Arterial/efeitos dos fármacos; Células CHO; Cricetulus; Diurese/efeitos dos fármacos; Fibrose; Furosemida/farmacologia; Insuficiência Cardíaca/metabolismo; Insuficiência Cardíaca/patologia; Insuficiência Cardíaca/fisiopatologia; Humanos; Masculino; Miócitos Cardíacos/efeitos dos fármacos; Miócitos Cardíacos/metabolismo; Miócitos Cardíacos/patologia; Osteopontina/metabolismo; Inibidor 1 de Ativador de Plasminogênio/metabolismo; Agregação Plaquetária/efeitos dos fármacos; Inibidores da Agregação Plaquetária/farmacologia; Ratos; Ratos Wistar; Receptores de Vasopressinas/genética; Receptores de Vasopressinas/metabolismo; Transdução de Sinais; Vasodilatação/efeitos dos fármacos; Vasodilatadores/farmacologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Vasopressinas / Antagonistas dos Receptores de Hormônios Antidiuréticos / Insuficiência Cardíaca Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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