Membrane mimetic systems in CryoEM: keeping membrane proteins in their native environment.
Curr Opin Struct Biol
; 58: 259-268, 2019 10.
Article
em En
| MEDLINE
| ID: mdl-31279500
ABSTRACT
Advances in electron microscopes, detectors and data processing algorithms have greatly facilitated the structural determination of many challenging integral membrane proteins that have been evasive to crystallization. These breakthroughs facilitate the application and development of various membrane protein solubilization approaches for structural studies, including reconstitution into lipid nanoparticles. In this review, we discuss various approaches for preparing transmembrane proteins for structural determination with single-particle electron cryo microscopy (cryoEM).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Microscopia Crioeletrônica
/
Proteínas de Membrana
/
Membranas Artificiais
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article