Building a Hybrid Physical-Statistical Classifier for Predicting the Effect of Variants Related to Protein-Drug Interactions.

Wang, Bo; Yan, Chengfei; Lou, Shaoke; Emani, Prashant; Li, Bian; Xu, Min; Kong, Xiangmeng; Meyerson, William; Yang, Yucheng T; Lee, Donghoon; Gerstein, Mark

Wang, Bo; Yan, Chengfei; Lou, Shaoke; Emani, Prashant; Li, Bian; Xu, Min; Kong, Xiangmeng; Meyerson, William; Yang, Yucheng T; Lee, Donghoon; Gerstein, Mark.

Afiliação

Wang B; Department of Chemistry, Yale University, New Haven, CT 06520, USA.
Yan C; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
Lou S; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
Emani P; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
Li B; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
Xu M; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
Kong X; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
Meyerson W; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA; Yale School of Medicine, Yale University, New Haven, CT 06520, USA.
Yang YT; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
Lee D; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA.
Gerstein M; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA; Department of Computer Science, Yale University, New Haven, CT 06520, USA. Electronic address: mark@gerstein

Structure ; 27(9): 1469-1481.e3, 2019 09 03.

Article em En | MEDLINE | ID: mdl-31279629

Assuntos

Biologia Computacional/métodos; Polimorfismo de Nucleotídeo Único; Proteínas/química; Proteínas/genética; Bases de Dados de Proteínas; Desenho de Fármacos; Humanos; Ligantes; Aprendizado de Máquina; Modelos Estatísticos; Simulação de Acoplamento Molecular; Ligação Proteica; Conformação Proteica; Proteínas/metabolismo

Palavras-chave

drug resistance; machine learning; nsSNV; protein-drug interactions

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas / Biologia Computacional / Polimorfismo de Nucleotídeo Único Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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