Chemical LTD, but not LTP, induces transient accumulation of gelsolin in dendritic spines.
Biol Chem
; 400(9): 1129-1139, 2019 08 27.
Article
em En
| MEDLINE
| ID: mdl-31280237
ABSTRACT
Synaptic plasticity underlies central brain functions, such as learning. Ca2+ signaling is involved in both strengthening and weakening of synapses, but it is still unclear how one signal molecule can induce two opposite outcomes. By identifying molecules, which can distinguish between signaling leading to weakening or strengthening, we can improve our understanding of how synaptic plasticity is regulated. Here, we tested gelsolin's response to the induction of chemical long-term potentiation (cLTP) or long-term depression (cLTD) in cultured rat hippocampal neurons. We show that gelsolin relocates from the dendritic shaft to dendritic spines upon cLTD induction while it did not show any relocalization upon cLTP induction. Dendritic spines are small actin-rich protrusions on dendrites, where LTD/LTP-responsive excitatory synapses are located. We propose that the LTD-induced modest - but relatively long-lasting - elevation of Ca2+ concentration increases the affinity of gelsolin to F-actin. As F-actin is enriched in dendritic spines, it is probable that increased affinity to F-actin induces the relocalization of gelsolin.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Potenciação de Longa Duração
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Gelsolina
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Depressão Sináptica de Longo Prazo
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Espinhas Dendríticas
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article